All About Anti Estrogens and Estrogen Blockers

Anti-estrogens and estrogen blockers

The word anti-estrogen is derived from the Greek word anti, which means “against.” This term refers to any compound that inhibits the effects of estrogen in the body.

While it’s common to believe that estrogen is only needed by women, the truth is that men require estrogen as well. This is because estrogen is involved in the cardiovascular, sexual, and hormone functions of the body. Especially for men, the use of anabolic steroids for cosmetic purposes or Testosterone replacement therapy (TRT) may have an effect on estrogen levels, resulting in a hormonal imbalance. 

This is where estrogen blockers or anti-estrogen drugs come in. They are designed to block or counteract the effects of estrogen and therefore provide a means of managing and regulating estrogen levels.

What Are Anti-Estrogen Drugs?

Anti-estrogen drugs work by blocking the effects of the sex hormone estrogen, a natural steroid hormone that regulates the female reproductive cycle. To correct estrogen dominance, a sex hormone imbalance, aromatase inhibitors are used to lower estrogen levels and anti-estrogen substances are used to block estrogen’s actions. Aromatase inhibitors prevent postmenopausal women and men from producing estrogen from androgens. Anti-estrogen compounds bind to estrogen receptors in cells, preventing them from being activated by estrogen. 

Anti-estrogen products are available by prescription in some countries, but they are also sold as over-the-counter dietary supplements in others. In some countries, they are available both by prescription and over-the-counter. Anti-estrogen supplements and aromatase inhibitors are commonly used by bodybuilders to improve muscle development and reduce steroid side effects. Tamoxifen is an anti-estrogen medication prescribed for premenopausal women who have estrogen-sensitive breast cancer. It binds to the estrogen receptors on cancer cells without activating them. 

Aromatase inhibitors are used to treat hormone-sensitive breast cancer in postmenopausal women. It is estimated that estrogen is required for the growth of 80% of breast cancers. In postmenopausal women, estrogen is produced from androgens in fatty tissues, including the breast. The supply to cancer cells is reduced by suppressing estrogen production. 

Can Estrogen Be Overproduced in The Body?

Can Estrogen be overproduced

Estrogen dominance is thought to be caused by dietary sources of plant estrogens and hormone-mimicking chemicals in the environment. Hormone imbalances can be caused by eating too much meat and dairy products from animals treated with hormones. Non-steroidal plant estrogens are found in a variety of plants and herbs, including soy, and may raise estrogen levels. In addition, estrogen-like hormone-mimicking chemicals are abundant in the environment. Plastics, agricultural chemicals, cosmetics, and household products are all sources. 

Using anabolic steroids is another way of raising estrogen levels in the body. This can lead to symptoms of estrogen dominance, including acne, excessive hair growth, and weight gain. Anabolic steroids have been linked to breast cancer and other health problems. They can cause changes in sex hormones and increase the risk of liver damage. 

What Are Estrogen Dominance Symptoms?

A common symptom of estrogen dominance is acne. It is caused by increased estrogen levels. When estrogen levels are too high, skin cells are activated and the sebaceous glands produce more oil. The oil then clogs the hair follicles and pores. This causes the follicles to swell and the hair to fall out. The result is blackheads, whiteheads, and pimples. 

Another symptom of estrogen dominance in men is gynecomastia. This is a swelling of the breasts, caused by an increase in estrogen levels. Gynecomastia is often accompanied by erectile dysfunction, loss of libido, and depression. 

How To Avoid Estrogen Overproduction in The Body

Avoiding Estrogen overproduction

Anti-estrogens are thought to counteract the effects of estrogen overexposure from food and the environment. Atherosclerosis in older women, early puberty in children, and the development of hormone-sensitive cancers have all been linked to too much estrogen. The rise in obesity rates could also be due to an excess of estrogen. Many chronic conditions, including declining male fertility, are thought to be caused by estrogen dominance. Anti-estrogens are used to counteract the negative effects of too much estrogen. 

Dietary changes can also help with estrogen dominance. Specific foods high in estrogen are avoided, while foods high in estrogen antagonists are promoted. The anti-estrogen diet eliminates conventionally produced meat and dairy products, as well as pesticide-laden fruits and vegetables. Organic foods, such as fresh vegetables, fruits, and organic animal products, should be consumed. The common button mushroom, cruciferous vegetables, and green tea are all foods that have a strong anti-estrogen effect.

Natural Anti-Estrogen Foods

These natural and legal anti estrogens may aid in estrogen blockage: 

  • Nettle root or nettle leaves — These are commonly used in prostate medications. Nettles contain compounds that act as natural estrogen blockers. Supplements can be used to control the hormone’s production. 
  • Chrysin — This is a flavonoid that is found in passionflower, honey, and bee propolis. Some claim it blocks estrogen and increases testosterone, while others claim there is no evidence. 
  • Maca — Maca is a cruciferous plant native to the Andes in Peru. Its proponents claim it has a slew of benefits, including improved fertility and estrogen blockade in men. Despite the fact that macaTrusted Source contains a variety of vitamins and nutrients, there is little scientific evidence that it helps regulate hormones. 
  • Grape seed extract — In postmenopausal women at high risk of breast cancer, grape seed extract acts as an aromatase inhibitor or estrogen blocker. It may provide similar benefits to men when taken as a supplement.

See also Nolvadex vs Arimidex: What Is Better for PCT?

Anti-Estrogen (Estrogen Blocking) Pills

Anti-Estrogen Pills

Estrogen blockers are medications that reduce estrogen production or its effects in the body. Here are a few anti estrogens for sale: 

  • Arimidex is a drug that is used to treat women with breast cancer. Some breast cancers grow more quickly as a result of a natural hormone called estrogen. Arimidex helps to slow or stop the progression of these breast cancers by lowering the amount of estrogen produced by the body. 
  • AromasinAromasin is a brand name for a prescription drug. It has been approved by the Food and Drug Administration (FDA) for the treatment of certain types of breast cancer. Aromasin contains the active ingredient exemestane. Aromasin is a type of endocrine therapy known as an aromatase inhibitor (also known as hormone therapy). Aromasin lowers estrogen levels in the body, making it harder for certain cancers to grow when estrogen levels are low. 
  • Cytadren is a hormone that affects the adrenal cortex, a part of the body. It affects steroid production as well as having other side effects. Cytadren is a medication that is used to treat adrenal cortex tumors. It’s also used to treat overactive adrenal cortex that isn’t cancerous. Cytadren can also be used to treat a number of other conditions, depending on your doctor’s recommendations. 
  • NolvadexNolvadex is a breast cancer treatment medication. It’s also used to reduce the risk of breast cancer in patients who are at a high risk. This drug can help to slow down the progression of breast cancer. It works by blocking estrogen’s action on breast tissue. 
  • ClomidClomid is also known as clomiphene citrate. It’s an oral medication commonly used to treat female infertility. Clomid works by convincing your body that your estrogen levels are lower than they actually are, causing your pituitary gland to secrete more follicle stimulating hormone (FSH) and luteinizing hormone (LH) (LH). FSH causes the ovary to produce one or more egg follicles, which develop and release during ovulation. High levels of LH cause ovulation to occur. Before referring a couple to a fertility specialist for further treatment, primary care physicians or OB-GYNs frequently prescribe Clomid. Some reproductive specialists also prescribe Clomid.


The above information is a summary and brief description of the types of anti-estrogen therapies that are available to help one regulate estrogen production in the body. 

Most of the drugs mentioned here are effective, but they may also have certain side effects and risks. It is best to discuss the pros and cons of these with your physician, as well as any other risks or side effects that you may be experiencing.

See also Role of Estrogen in Bodybuilding: What You Need to Know

Role of Estrogen in Bodybuilding: What You Need to Know

Role of Estrogen in bodybuilding

Estrogen is commonly referred to as a “female hormone,” but this is a misnomer because this steroid hormone is produced in both male and female bodies. It’s also true that women produce far more estrogen than men, just as men produce roughly 10 times the amount of testosterone that women do. 

Men’s higher testosterone levels are frequently cited as the reason for their ability to gain muscle mass faster than women. Recent studies, on the other hand, show that despite producing negligible amounts of testosterone while weight training, women can achieve similar muscle gains as men. That has to do with the fact that anabolic hormones released during exercise don’t have as much of an impact on muscle growth as previously thought.

Estrogen’s Role in Bodybuilding

Bodybuilders despise the word estrogen. The hormone has been linked to an increase in subcutaneous body fat and water retention. Gynecomastia is a female-type breast development that occurs in male bodybuilders who use anabolic steroids that convert to estrogen. They often use drugs that stop estrogen from getting into cells, like Nolvadex, or drugs that stop the enzymes that make androgens into estrogen, called aromatase blockers, to keep this and other estrogen-related effects from happening. Some bodybuilders are so afraid of estrogen that they take anti-estrogen drugs all year, assuming they are harmless. 

Many bodybuilders are unaware of the crucial role estrogen plays in muscle growth and training. When women exercise, they experience less muscle damage, which is attributed to estrogen, which acts as an anti-inflammatory during exercise. When women exercise, they burn more fat than men, though this isn’t as noticeable because most women have higher bodyfat levels than men. The reason for this is that women produce more growth hormone, which helps to mobilize fat. Women also do not respond to carbohydrate loading techniques, which is thought to be due to their higher estrogen levels. 

Bodybuilders have long been told that a certain amount of estrogen is required to maintain androgen cell receptors, which interact with testosterone to produce anabolic effects in muscle. Recent research, on the other hand, suggests that estrogens may play an even more direct role in muscle development.

What is Aromatization?

What is Aromatization

In terms of bodybuilding, aromatization is all about how your body reacts to having more estrogen in your body. This is why many bodybuilders take anti-estrogen pills for bodybuilding.

There is a process called aromatization that turns testosterone into estrogen. That process is normal. Every anabolic steroid that is made is a form of testosterone that is meant to make men more attractive both sexually and physically. 

It is natural for testosterone to turn into estrogen, but many bodybuilders don’t like the idea of their testosterone levels turning into estrogen. As long as men aren’t growing breast tissue, estrogen is not bad. 

There is a lot of estrogen in males, which is why we say it isn’t so bad. Too much of it is bad.

Should I Take Estrogen Blockers?

Should I Take Estrogen Blockers

Estrogen blockers aid in increasing testosterone levels, which is one of the primary reasons for their use. For those of you who aren’t familiar with testosterone, it’s the male hormone that is responsible for promoting muscle growth; improving mood and energy; and increasing sex drive. As a result, when you have a healthy level of testosterone in your body, you’ll be able to perform at a high level. 

Bodybuilders should also take estrogen blockers because of the positive impact they have on their cardiovascular health. Since this is the case, working out vigorously will not cause you to become out of breath, allowing you to build the muscular arms you’ve always wanted! 

In a nutshell, steroids have been shown to raise estrogen levels in the body. Taking estrogen-blocking supplements can help bodybuilders avoid the effects of estrogen overdose, such as weight gain and bloating.

Best Estrogen Blocker For Bodybuilding

Best Estrogen blocker

Estrogen blockers are drugs that cut down on either the production or the effects of estrogen in your body. Some of them are: 

  • Arimidex – Arimidex is used to treat breast cancer in women. A natural hormone called estrogen causes some breast cancers to grow more quickly. Arimidex reduces the amount of estrogen produced by the body, which helps to slow or stop the progression of these breast cancers.
  • AromasinAromasin is a prescription drug with a brand name. The FDA has approved it for the treatment of certain types of breast cancer. Exemestane is the active ingredient in Aromasin. Aromasin is an aromatase inhibitor, which is a type of endocrine therapy (also known as hormone therapy). Aromasin decreases estrogen in the body, giving certain cancers less fuel to grow when estrogen levels are low.
  • Cytadren – Cytadren affects the adrenal cortex, which is a part of the body. It has an impact on steroid production as well as other side effects. Cytadren is a drug that is used to treat tumors of the adrenal cortex. It’s also used in cases where the adrenal cortex is overactive but not cancerous. Cytadren can also be used to treat a variety of other conditions as determined by your doctor.
  • Nolvadex – Nolvadex is a medication that is used to treat breast cancer. It’s also used to lower the risk of breast cancer in patients who are at high risk of the disease. This medication has the ability to slow the progression of breast cancer. It works by preventing estrogen from acting on the breast tissue.
  • Clomid – Clomiphene citrate is another name for Clomid. It’s an oral medication that’s commonly used to treat infertility in women. Clomid works by tricking your body into thinking your estrogen levels are lower than they are, causing your pituitary gland to secrete more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH stimulates the ovary to produce an egg follicle, or multiple follicles, which develop and release during ovulation. Ovulation is stimulated by high levels of LH. Clomid is frequently prescribed by primary care physicians or OB-GYNs before referring a couple to a fertility specialist for further treatment. Clomid is also prescribed by some reproductive specialists.

Most of these drugs were made to fight breast cancer because estrogens can be bad for women’s breast tissue. They work very well. In some cases, they can cut estrogen levels by 90% or more. 

In order for estrogen-blocking drugs to work, they have to suppress natural estrogen production or make the estrogen that’s been naturally produced have less effects in the body.

By blocking this enzyme, many estrogen blockers reduce the amount of testosterone that is transformed into estrogen. 

Some also prevent the cell receptors from receiving estrogen, allowing it to circulate aimlessly in your body before being excreted.

See also Letrozole for Fertility: Benefits, Side Effects, and More

Are Estrogen Blockers Safe?

Estrogen blockers have been shown to be safe when used for short periods of time (a few months), but there is evidence that long-term use can cause health problems. 

These drugs, for example, have been shown to increase the risk of bone demineralization and fracture, osteoporosis and joint pain, and increased risk of heart disease and stroke, among other things.

Hot flashes, constipation, vertigo, skin itching, nausea, and depression are all known side effects of estrogen blockers, too. 

It’s worth noting, however, that the majority of the human research on these drugs has been done on women who are battling breast cancer, so we might not see the same results in healthy people. 

If you take estrogen blockers in high doses, you can almost certainly expect to experience some negative side effects. Artificially increasing estrogen levels, like artificially decreasing estrogen levels, would disrupt your physiology to some degree. However, there is also a ton of anecdotal evidence that suggests the use of estrogen blockers is generally safe when used in small doses.


When you’re a bodybuilder, it’s only natural that you’ll have to stay fit and healthy on the inside. You don’t have to be concerned if you’re looking for alternatives to estrogen blockers to keep your estrogen levels in check. This is due to the fact that there are numerous options. 

One of the first methods is to exercise consistently throughout the week. In addition to other exercises, weight lifting can have a positive effect on your hormones.

Another way to do so is to maintain a healthy diet. Your diet should provide enough nutrients to keep your hormones in check. Furthermore, eating well will make you feel and appear lighter and healthier! 

Estrogen blockers, without a doubt, can greatly assist bodybuilders by lowering estrogen levels and increasing testosterone levels. This, in turn, will benefit you in terms of gaining mass and possibly even achieving the body of your dreams!

See also Post Cycle Therapy: What to Expect After a Steroid Cycle?

Nolvadex vs Arimidex: What Is Better for PCT?

Nolvadex vs Arimidex

Because AIs like Arimidex truly prevent estrogen function, whereas SERMs like Nolvadex are very specific in how and where they can block estrogen function, more bodybuilders are turning to AIs like Arimidex to meet their needs for a powerful anti-estrogen after using steroids. However, many of us continue to use Nolvadex and other SERMs, often in combination with AIs. 

What’s the difference between Nolvadex and Arimidex, and do you need to use a SERM at all? It all comes down to how your body reacts to steroids, the severity of your steroid cycle, and the adverse effects that come with it.

Arimidex Vs Nolvadex

While Arimidex and AIs are likely to negatively influence your cholesterol by lowering HDL cholesterol – the good cholesterol type – and this is magnified when used with most anabolic steroids, Nolvadex and other SERMs do not. 

In fact, Nolvadex has the potential to be beneficial to cholesterol, in contrast to Arimidex. This is a major reason why individuals prefer SERMs to AIs like Arimidex, especially during milder steroid cycles where an AI isn’t required. 

However, Nolvadex has another significant advantage: it is particularly effective during post-cycle therapy to increase natural testosterone production after a steroid cycle has been suppressed. 

While Arimidex and SERMs in general have some testosterone-stimulating effects, the way Arimidex suppresses estrogen levels to the point where there aren’t enough for normal functioning results in testosterone stimulation that is weak and infrequent. 

As a result, Arimidex is rarely suggested for use during post-cycle therapy and is instead thought to be a medicine that is best utilized during a steroid cycle, where it outperforms Nolvadex in terms of performance and results. That isn’t to suggest that bodybuilders don’t use Arimidex during post-cycle therapy; many do, but only in combination with other pharmaceuticals to ensure that every conceivable angle is covered in order to aid in complete recovery from a powerful steroid cycle. 

When people don’t want to use Arimidex during post-cycle therapy, they commonly utilize a combination of Clomid, Nolvadex, and hCG instead. The ultimate goal of post-cycle therapy is to increase testosterone not only for normal male function, but also to maintain muscular gains and reduce body fat, both of which suffer when testosterone levels are low.

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Arimidex Side Effects

Arimidex Side Effects

As a women’s medicine, the majority of the adverse effects documented are related to Arimidex’s influence on the female body, namely how the large drop of estrogen causes most of these side effects. 

Because estrogen is the principal female sex hormone, it is obvious that when Arimidex reduces estrogen levels to the extent it does, it will have a significant influence on females — yet when men use Arimidex, estrogen reduction is generally welcomed rather than a treated as a burden. Furthermore, when used as a breast cancer treatment, Arimidex is nearly always taken for far longer lengths of time than it is used by steroid users. 

All of this isn’t to say that steroid users who take Arimidex won’t experience adverse effects, but they won’t be as widespread or severe. One of the main concerns is a possible decrease in bone mineral content (BMC), which might increase the risk of fractures and bone fragility, particularly in persons who lift large weights. 

While most steroid users are unlikely to notice a loss in bone mineral content with Arimidex, some bone or joint pain may develop, which normally goes away once the medicine is stopped. This negative effect is much less of a concern for steroid users because many steroids actually increase BMC. 

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The second most alarming Arimidex side effect is high cholesterol. Arimidex can exacerbate the effects of several types of anabolic steroids, which are known to have a negative impact on HDL cholesterol levels by reducing them (sometimes dramatically). 

While a decrease in HDL is almost always reversible after taking steroids, it’s still necessary to eat a low-saturated-fat, high-cholesterol-friendly diet that includes foods high in omega-3 fatty acids. 

Cardio exercise is also recommended to keep cholesterol levels as low as possible throughout this period. If you have a history of elevated cholesterol, using a SERM rather than an AI like Arimidex to manage on-cycle estrogen levels will help you avoid this problem. 

Fatigue, headache, nausea, and hot flashes are among the less common Arimidex side effects, but these are virtually always only encountered in women who take the drug for a long time.

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Nolvadex Side Effects

Nolvadex Side Effects


Most of the side effects associated with Nolvadex is related to women and is in the area of its use as a breast cancer treatment SERM. However, because male anabolic steroid users have used it for a long time, there is enough anecdotal evidence for us to say with certainty what side effects are common. 

Read also about Nolvadex dose

Not only does the drug react differently in the female body, but when used as a cancer medication, it is used for a much longer period of time. As a result, when it comes to your use of Nolvadex as a PCT, these long-term side effects can be reduced to a bare minimum. 

So, what are some of the most common side effects to be aware of when using Nolvadex, whether for post cycle therapy or while on a cycle? 

Acne. This is thought to be the most likely Nolvadex side effect. This is because your testosterone levels will start to rise, and acne is a natural side effect of rising testosterone levels in some men; however, not all men are predisposed to acne, and if you aren’t, you won’t experience this side effect. Acne is usually mild and goes away once the medication is stopped. 

Nausea or abdominal cramping. This is another side effect but the vast majority of men won’t experience it while taking Nolvadex. 

Impaired cognitive function and hot flashes have been reported in women who use Nolvadex for cancer treatment. These side effects, however, are not known to be a risk factor for men who use this drug for bodybuilding or performance enhancement purposes. 

The best way to reduce or eliminate the risk of long-term side effects when using Nolvadex is to keep the dosage at a reasonable level. Because there is no benefit to taking more Nolvadex than is recommended, adhering to the recommended dosage is critical for both results and health.

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Arimidex Vs Nolvadex for Post Cycle Therapy?

Arimidex vs Nolvadex

So, should you take Arimidex or Nolvadex for bodybuilding? The answer is complicated because it depends on a variety of factors, including your unique hormonal profile and the type of steroid cycle you’re using. However, in many cases, using both drugs together can be beneficial. 

Because Arimidex and Nolvadex work in different ways, a combination of the two may be beneficial. Nolvadex and Arimidex both work by binding to estrogen receptors and inhibiting the aromatase enzyme. This means that combining the two drugs can provide a more comprehensive estrogen control strategy. 

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Arimidex Advantages 

  • Arimidex is an effective aromatase inhibitor that can help to lower estrogen levels in the body. This could be advantageous for bodybuilders who want to avoid the negative effects of this hormone. 
  • Arimidex is also a powerful drug that works by blocking the aromatase enzyme. This makes it an excellent choice for bodybuilders who want to reduce estrogen levels in their bodies. 
  • Arimidex is a long-acting drug, which means it can suppress estrogen for the duration of your cycle. This can be advantageous for bodybuilders who want to achieve the best possible results. 

Nolvadex Advantages 

  • Nolvadex is a SERM (selective estrogen receptor modulator) that can help to lower estrogen levels in the body. This could be advantageous for bodybuilders who want to avoid the negative effects of this hormone. 
  • Because Nolvadex is a long-acting drug, it can provide estrogen suppression for the duration of your cycle. This can be advantageous for bodybuilders who want to achieve the best possible results. 
  • Nolvadex is a relatively inexpensive drug, making it a good choice for budget-conscious bodybuilders.


So, what’s the best drug to use for post cycle therapy? That’s a difficult question to answer because there are a number of factors to consider, including the type of cycle you’re using and your unique hormonal profile. However, the most important thing to remember is that it’s not one drug or another that’s going to be most effective for you. It’s a combination of drugs and the dosage that you take.

See also info about Nolvadex Side Effects

Arimidex is an estrogen-blocking drug that is used to treat gynecomastia and edema caused by steroid use. Arimidex works by preventing testosterone from being converted to estrogen by inhibiting the aromatase enzyme. Nolvadex is a selective estrogen receptor modulator (SERM) that binds to and inhibits the activation of estrogen receptors. 

Arimidex and Nolvadex are two drugs that can be used for post-cycle therapy in general. It’s crucial to talk to your doctor before taking either drug to make sure it’s right for you.

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